A modular plant virus-derived

nanoparticle for drug vectorization

High potential of loading various types of active ingredients (proteins, peptides, small molecules, mRNA) on several applications (therapeutic and prophylactic vaccination, precision therapies, etc.)

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Efficacy

More bioavailability thanks to an API protection
Specific delivery with a custom cell-targeting
Efficient delivery due to a limited risk of pre-existing antibodies against the plant-based nanoparticle
More thermostability during storage and transportation

Safety

Low dosage thanks to API concentration in a nanoparticle
Low levels of harmful impurities due to a plant-based bioproduction process free of human pathogens
No off-target effects due to the cell-targeting selectivity

Versatility

High index of nanoparticle’s modularity: tailor-made API type, cell-targeting and administration
Quality by Design of the particle: from the desired mode of action to a custom design of a drug

Efficiency

Low development cost thanks to a plant-based manufacturing process
Quick development thanks to a fast-to-test bioprocess
Batch size adaptation thanks to upscaling and downscaling flexibility offered by the plants (1 plant = 1 bioreactor)

Application N°1 in immuno-oncology

An innovative immunization system for unlocking the full potential of

therapeutic cancer vaccines

The concept

The nanotechnology is adapted into an effective immunization system to trigger antitumoral T immune response, needed to fight cancer cells.

The design of the particle is based on the desired mode of action which is unique.

By directly targeting the most efficient antigen-presenting immune cells and by delivering tumor-derived antigens to them, the platform is able to activate the immune system and induce strong cytotoxic immune responses against the tumor. In vitro and in vivo results demonstrate the concept.

The production is simple: the drug substance (immunization system + antigens) is produced in one step in plants allowing a fast, human pathogens-free and cost-effective production.

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A tailor-made immunization system

for vaccines

Bioproduction

Safe, fast-to-test, scalable plant-based transient expression system.

Payload

Already tested: Antigens in the form of small proteins or peptide chains
To be explored: mRNA, small molecules

Surface display

Already tested: Cell-targeting antibodies or antibody fragments. Genetic fusion or ligand-mediated
To be explored: direct conjugation of adjuvant to the surface (auto-adjuvant particle)